遺伝子機能応用学研究室

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研究実績
 
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2001年

  • 特願 2001-212354,発明の名称;熱ショック蛋白質の合成抑制及び機能抑制剤,出願人:甲斐広文(2001)

  • 国内出願番号:特願2001-034986, 発明の名称: ETS転写因子又はそれをコードする遺伝子からなる上皮細胞のGM-CSF,及び/又はディフェンシン
    蛋白質の発現調節剤,出願人:甲斐広文 (2001)

  • 国内出願番号:特願2001-034834, 発明の名称: ETS転写因子又はそれをコードする遺伝子からなる細胞増殖抑制剤,出願人:甲斐広文(2001)

  • Nagayama S, Jono H, Suzaki H, Sakai K, Tsuruya E, Yamatsu I, Isohama Y, Miyata T, Kai H.  Carbenoxolone, a new inducer of heat shock protein 70. Life Sci. 2001;69(24):2867-73.

  • Komori T, Kai H, Shimoishi K, Kabu K, Nonaka A, Maruyama T, Tamura K, Otagiri M.  Up-regulation by clarithromycin of alpha(1)-acid glycoprotein expression in liver and primary cultured hepatocytes. Biochem Pharmacol. 2001;62(10):1391-7.

  • Shuto T, Xu H, Wang B, Han J, Kai H, Gu XX, Murphy TF, Lim DJ, Li JD.  Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha /beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells. Proc Natl Acad Sci U S A. 2001;98(15):8774-9.

  • Takahashi K, Kai H, Mizuno H, Koda T, Miyata T.  Effect of fudosteine, a new cysteine derivative, on mucociliary transport.
    J Pharm Pharmacol. 2001;53(6):911-4.

  • Shimoishi K, Kai H, Kabu K, Komori T, Maruyama T, Otagiri M. FK506 (tacrolimus) increases rat alpha1-acid glycoprotein expression in liver and primary cultured hepatocytes. Eur J Pharmacol. 2001;420(2-3):91-5.

  • Isohama Y, Kanemaru M, Kai H, Takahama K, Miyata T.  Interaction between beta-adrenergic signaling and protein kinase C increases cytoplasmic Ca2+ in alveolar type II cells. Life Sci. 2001;68(21):2361-71.

  • N. Ono, F. Hirayama, H. Arima, K. Uekama, Analysis of the phase solubility diagram of a phenacetin/competitor/ b-cyclodextrin ternary system, involving competitive inclusion complexation. Chem. Pharm. Bull., 49, 78-81, 2001.

  • N. Ono, H. Arima, F. Hirayama and K. Uekama. A Moderate interaction of maltosyl-a-cyclodextrin with caco-2 cells in comparison with the parent cyclodextrin. Biol. Pharm. Bull., 24, 395-402, 2001.

  • H. Arima, K. Yumomae, K. Miyake, T. Irie, F. Hirayama and K. Uekama, Comparative studies of the enhancing effects of cyclodextrins on the solubility and oral bioavailability of tacrolimus in rats. J. Pharm. Sci., 90, 690-701, 2001.

  • H. Arima, K. Yunomae, F. Hirayama and K. Uekama, Contribution of P-glycoprotein to the enhancing effects of dimethyl-b-cyclodextrin on oral bioavailability of tacrolimus. J. Pharmacol. Exp. Ther., 297, 547-555, 2001.

  • H. Arima, F. Kihara, F. Hirayama and K. Uekama, Enhancement of gene expression by polyamidoamine dendrimer conjugates with a-, b- and g-cyclodextrins. Bioconjugate Chem., 12, 476-484, 2001.

  • H. Arima, Y. Nishimoto, K. Motoyama, F. Hirayama and K. Uekama, Inhibitory effects of novel hydrophilic cyclodextrin derivatives on nitric oxide production in macrophages stimulated with lipopolysaccharide. Pharm. Res., 18, 1167-1173, 2001.

  • H. Yano, F. Hirayama, H. Arima, K. Uekama, Prednisolone-appended a-cyclodextrin: alleviation of systemic adverse effect of prednisolone after intracolonic administration in 2,4,6-trinitrobenzenesulfonic acid-induced colitis rats. J. Pharm. Sci., 90, 493-503, 2001.

  • H. Yano, M. Kamada, F. Hirayama, H. Arima, K. Uekama, Prednisolone-appended a-cyclodextrin conjugate: drug release in rat biological fluids and anti-inflammatory effect after oral administration to 2,4,6-trinitrobenzenesulfonic acid-induced colitis rats, J. Pharm. Sci., 90, 2103-2112, 2001

  • K. Uekama, Y. Hieda, F. Hirayama, H. Arima, M. Sudoh, A. Yagi, and H. Terashima, The Stabilizing and solubilizing effects of sulphobutyl ether b-Cyclodextrin (SBE-b-CyD) on prostaglandin E1 analogue. Pharm. Res., 18, 1578-1585, 2001.

  • Y. Nagase, M. Hirata, K. Wada, H. Arima, F. Hirayama, T. Irie, M. Kikuchi, and K. Uekama, Interaction of DY-9760e, a Novel Cytoprotective agent with positive charge, with sulfobutyl ether β-cyclodextrin and 2-hydroxypropyl-b-cyclodextrin: Improvements of solubility, photo-stability and adsorption. Int. J. Pharm., 229, 163-172, 2001.

  • H. Matsuda, M. Yamaguchi and H. Arima, Separation and crystallization of oleaginous constituents in cosmetics: Sweating and blooming. メCrystallization Processes in Fats and Lipid Systemsモ, Marcel Dekker, Inc., New York, pp. 485-503, 2001.

  • Cyclodextrin-dendrimer conjugates as gene transfection vector. Arima, Hidetoshi; Kihara, Fumihiro; Uegama, Kaneto. (Nihon Shokuhin Kako K. K., Japan). Jpn. Kokai Tokkyo Koho (2001), 10 pp. CODEN: JKXXAF JP 2001103969 A2 20010417 Patent written in Japanese. Application: JP 99-288792 19991008. CAN 134:276488 AN 2001:270155 CAPLUS
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