遺伝子機能応用学研究室

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研究実績
 
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17th Congress of the International Pediatoric Nephrology Association (IPNA) (2016. 9. 20-24) Iguacu, Brazil
CLARIFY THE INTRACELLULAR STRESS RESPONSE IN EARLY-STAGE ALPORT SYNDROME AND ESTABLISH AN EVALUATION SYSTEM FOR INTRACELLULAR REGULATION OF COL4A5
K. OMACHI, K. TERAMOTO, M. KAMURA, H. KOJIMA, T. YOKOTA, M.A. SUICO, T. SHUTO, H. KAI

16th International Congress of Immunology (ICI2016) (2016. 8. 21-26) Merborne, Australia
Mild electrical stimulation with heat shock suppresses skin hyperplasia in imiquimod-induced psoriasis model.
Tsurekawa Y, Kai Y, Morita M, Takada M, Moriuchi M, Okita G, Suico MA, Shuto T, Kai H

3rd International Conference on Chronic Obstructive Pulmonary Disease 2016 (COPD2016) (2016. 7. 11-12) Brisbane, Australia
Pharmacological and genetic approaches determine protease and oxidative stress as exacerbating factors in a mouse model of obstructive lung diseases
Tsuyoshi Shuto

Best Poster Award
Plasma uric acid as a protective factor of respiratory dysfunction and emphysema in female mice and human with obstructive pulmonary diseases
Haruka Fujikawa

GLP-1 receptor agonist exacerbates mucus hyper secretory phenotype in βENaC-transgenic mouse with obstructive lung diseases
Hirofumi Nohara

2015 cell biology ascb annual meeting(2015.12.12-16) San Diego Convention Center, San Diego, CA
"Molecular mechanism of the intracellular quality control of TTR by Hsp47 "
Y. Wakita, R. Yamakawa, K. Chosa, S. Takaki, Y. Teranishi, T. Sato, M.Suico, T. Shuto, H. Kai

"A novel physiological and pathophysiological role of glucagon-like peptid-1 signal in the regulation of airway mucin secretion "
H. Nohara, T. Shuto, S. Kamei, R. Nakashima, S. Kamei, H. Fujikawa, K. Maruta, M. Suico, D.C. Gruenert, H. Kai

"A novel splicing variant of zinc transporter ZIP2 controls the pathology of CF and CF-like airway diseases. "
S. Kamei, T. Shuto, K. Shuto, H. Fujikawa, K. Maruta, H. Nohara, R. Nakashima, M. Suico, D.C. Gruenert, H. Kai

"Glomerular proteome analysis revealed progressive mitochondrial dysfunction in Alport syndrome mouse model "
M. Kamura, K. Omachi, T. Yokota, K. Motomura, K. Teramoto, M. Suico, T. Shuto, H. Kai

International Symposium on Chronic Inflammatory Diseases, Kumamoto (ISCIDK2015)(2015.10.16-17) Kumamoto Unv., Kumamoto, Japan
"Beneficial effects and the molecular mechanisms of specific mild electrical stress as physical medicine "
H. Kai, T. Kondo, M.A. Suico, T. Shuto E. Araki

"Podocyte p53 limits the severity of experimental Alport syndrome "
M.A. Suico, R. Fukuda, Y. Kai, K. Omachi, K. Motomura, T. Koga, K. Koyama, T. Yokota, M. Taura, T. Shuto, H. Kai

"Pharmacological and genetic approaches determine protease and oxidative stress as exacerbating factors in a mouse model of obstructive lung diseases "
T. Shuto, S. Kamei, H. Nohara, H. Fujikawa, Y. Sakaguchi, C. Matsumoto, T. Ono, T. Sugahara, M.A. Suico, K. Mitsutake, H. Kai

"Clarify the intracellular stress response in early-stage Alport Syndrome (AS) and establish an evaluation system for intracellular regulation of COL4A5, the causal protein for AS "
K. Omachi, M. Kamura, K. Teramoto, T. Yokota, K. Motomura, R. Fukuda, M. Suico, T. Shuto, H. Kai

"Establishment of fluorescence resonance energy transfer (FRET) system that monitors the trimerization of COL4A proteins, the causal proteins for Alport syndrome "
K. Teramoto, K. Omachi, M. Kamura, M. Suico, T. Shuto, H. Kai

"Glomerular proteome analysis reveals progressive mitochondrial dysfunction in Alport syndrome mouse model "
M. Kamura, K. Omachi, K. Teramoto, T. Yokota, K. Motomura, S. Kotani, M. Suico, T. Shuto, S. Misumi, H. Kai

"p53 exacerbates LPS-induced acute kidney injury possibly through TLR4 up-regulation in podocyte "
K. Motomura, R. Fukuda, T Yokota, M. Suico, T. Shuto, H. Kai

"FAM105A suppresses lipopolysaccharide-induced inflammatory response in human monocytes THP-1 "
T. Yokota, R. Fukuda, M. Suico, T. Shuto, T. Koga, K. Koyama, H. Kai

"IncuCyte-based non-invasive method of analyzing the life span of C. elegans "
M. Moriuchi, T. Shuto, Y. Nakano, M. Suico, K. Nanri, T. Ueno, H. Kai

"The immunosuppressive effect of mild electrical stimulation via NFAT pathway is a promising therapeutic approach for inflammation "
M. Piruzyan, I. Shitanda, Y. Shimauchi, M. Suico, T. Shuto, H. Kai

"Mild electrical stimulation suppresses IL22 mRNA expression in imiquimod-induced psoriasis mouse model "
Y. Tsurekawa, M. Suico, M. Moriuchi, G. Okita, Y. Nakano, M. Piruzyan, M. Takada, M. Morita, T. Shuto, H. Kai

"Mild Pulse Electrical Stimulation regulates Alzheimer’s disease pathology"
G. Okita, M. Takada, K. Mitsutake, T. Shuto, M. Suico, H. Kai

"High-fat diet exaggerates pulmonary dysfunction and emphysema in a mouse model of obstructive lung diseases:Possible contribution of local insulin resistance in lung tissue "
H. Nohara, T. Shuto, S. Kamei, H. Fujikawa, R. Nakashima, K. Maruta, M. Suico, D.C. Gruenert, H. Kai

"Physiological and pathophysiological induction of pulmonary mucus hypersecretionby GLP-1 receptor agonist Exendin-4"
H. Nohara, R. Nakashima, T. Shuto, S. Kamei, H. Fujikawa, K. Maruta, C. Matsumoto, Y. Sakaguchi, M. Suico, D.C. Gruenert, H. Kai

"The effect of Uricase inhibitor on respiratory function and emphysema in murine models of obstructive pulmonary disease"
H. Fujikawa, T. Shuto, S. Kamei, H. Nohara, K. Maruta, R. Nakashima, M. Suico, T. Takeo, N. Nakagata, H. Kai

"A novel splicing variant of zinc transporter ZIP2 controls the pathology of CF and CF-like airway diseases"
S. Kamei, T. Shuto, K. Ueno-Shuto, H. Fujikawa, K. Maruta, H. Nohara, R. Nakashima, C. Matsumoto, Y. Sakaguchi, M. Suico, D.C. Gruenert, H. Kai

"CFTR-dependent dysregulation of specific lncRNAs with unknown function in cystic fibrosis airway epithelial cells"
S. Kamei, K. Maruta, T. Shuto, H. Fujikawa, H. Nohara, R. Nakashima, Y. Tasaki, K. Ueno-Shuto, M. Suico, D.C. Gruenert, H. Kai

"6-benzoyl-2-hydroxy-1H-benzo[de]isoquin oline-1,3(2H)-dione is a novel transthyretin stabilizer for familial amyloid polyneuropathy"
S. Takaki, K. Chosa, T. Yokoyama, Y. Teranishi, Y. Wakita, T. Sato, M. Suico, T. Shuto, M. Mizuguchi, H. Kai

"High throughput screening-based identification of transthyretin stabilizers for familial amyloid polyneuropathy"
Y. Teranishi, K. Chosa, T. Shuto, S. Takaki, Y. Wakita, T. Sato, M. Suico, T. Yamashita, H. Kai

"The molecular quality control of TTR by Hsp47 "
Y. Wakita, R. Yamakawa, K. Chosa, S. Takaki, Y. Teranishi, T. Sato, S. Ann, T. Shuto, H. Kai

The 74th Annual Meeting of the Japanese Cancer Association(2015.10.8-10) Nagoya Congress Center, Nagoya, Japan
"Myeloid Elf-1-like Factor (MEF)/Elf-4 is Induced by HIF1/Hypoxia and contributes to VEGF regulation "
Mary Ann Suico, Manabu Taura, Eriko Kudo, Tsuyoshi Shuto, Seiji Okada, Hirofumi Kai

The 2015 International workshop on Alport Syndrome(2015.9.25-27), Germany
Award for the best poster presentation
Cellular-based assay clarifies the regulation of Alport syndrome-related protein COL4A5
K. Omachi

Award for the best young investigator presentation
Glomerular Proteome Analysis Revealed Progressive Mitochondrial Dysfunction in Alport Syndrome Mouse Model
M. Kamura

52nd ERA-EDTA CONGRESS LONDON 2015(2015.5.28-31)
ExCeL London, London, UK

"Characterization of the intracellular behavior of COL4A5 and clarification of molecular mechanism of alport syndrome"
K. Omachi, M. Kamura, K. Teramoto, R. Fukuda, M. Suico, T. Shuto, H. Kai

「修飾シグナル病」第2回国際シンポジウム(2015.1.23-24)
東京大学医科学研究所, 東京

"Podocyte-p53 is essential to control the progression of hereditary renal disease Alport syndrome"
H. Kai

Pharmacology 2014(2014.12.16-18)
Queen Elizabeth II Conference Centre, London, UK

"Podocyte-specific p53 Deletion Promotes Alport Syndrome Progression by Enhancement of Podocyte Proliferation and Migration"
R. Fukuda, Y. Kai, K. Omachi, K. Motomura, T. Koga, K. Koyama, M. A. Suico, T. Shuto, H. Kai

The 2014 ascb/ifcb Meeting(2014.12.6-10)
Pennsylvania Convention Center, Philadelphia, PA

"The effect of Mild Electrical Stimulation with Heat Shock on kidney dysfunction in type 2 diabetic KKAy mice. "
Y. Kai, R. Fukuda, K. Omachi, Y. Okamoto, M. Suico, T. Shuto, H. Kai

"Screening of small compounds to develop endoplasmic reticulum-oriented drug for familial amyloid polyneuropathy. "
K. Chosa, S. Takaki, R. Yamakawa, Y. Wakita, Y. Teranishi, T. Sato, T. Yokoyama, M. Mizuguchi, M. Suico, T. Shuto, H. Kai

"Characterization of the Intracellular Behavior of COL4A5 and Clarification of Molecular Mechanism of Alport Syndrome. "
K. Omachi, M. Kamura, K. Teramoto, R. Fukuda, M. Suico, T. Shuto, H. Kai

The ASN Kidney Week 2014 Annual Meeting(2014.11.13-16)
Pennsylvania Convention Center, Philadelphia, PA

"Podocyte-specific p53 Deletion Promotes Alport Syndrome Progression by Enhancement of Podocyte Proliferation and Migration"
R. Fukuda, Y. Kai, K. Omachi, K. Motomura, T. Koga, K. Koyama, M. A. Suico, T. Shuto, H. Kai

28th Annual North American Cystic Fibrosis Conference(2014.10.9-11)
Georgia World Congress Center, Atlanta, GA

"GLP-1 RECEPTOR AGONIST EXTENDIN-4 EXACERBATES MUCUS HYPERSECRETORY PHENOTYPE IN EPITHELIAL NA+ CHANNEL-OVEREXPRESSING CELLS AND MICE"
H. Nohara, T. Shuto, S. Kamei, H. Fujikawa, MA. Suico, RA. Caldwell, DC. Gruenert, H. Kai

The 4th International ISZB Meeting(2014.9.14-19)
Asilomar, Pacific Grove, CA

"Aberrant splicing of zinc transporter ZIP2 in cystic fibrosis airway epithelial cells "
T. Shuto, S. Kamei, K. Ueno-Shuto, H. Fujikawa, H. Nohara, C. Matsumoto, Y. Sakaguchi, M. Suico, H. Kai

KEY Forum: From Stem Cells to Organs
熊本医学・生物科学国際シンポジウム「幹細胞制御と臓器再建」(2014.9.4-5)
熊本市医師会館

"The endoplasmic reticulum-oriented drug development for familial amyloid polyneuropathy "
K. Chosa, R. Yamakawa, T. Sato, T. Yokoyama, M. Mizuguchi, M. Suico, T. Shuto, H. Kai

"VITAMIN C DEFICIENCY EXACERBATES RESPIRATORY FUNCTION AND EMPHYSEMA IN EPITHELIAL NA+ CHANNEL-OVEREXPRESSING MICE "
H. Fujikawa, Y. Sakaguchi, T. Shuto, H. Nohara, S. Kamei, Y. Kondo, MA. Suico, A. Ishigami, H. Kai

"Podocyte-specific p53 deletion promotes progression of Alport syndrome by enhancement of podocyte proliferation and migration"
R. Fukuda, Y. Kai, K. Omachi, K. Motomura, T. Koga, K. Koyama, M. A. Suico, T. Shuto, H. Kai

"Aberrant splicing of zinc transporter ZIP2 causes mucus hypersecretory phenotype in CF airway epithelial cells "
S. Kamei, T. Shuto, K. Ueno-Shuto, H. Fujikawa, H. Nohara, C. Matsumoto, Y. Sakaguchi, M. Suico, R. A. Caldwell, D. C. Gruenert, H. Kai

"Glomerular Proteome Analysis for Establishment of New Therapeutic Strategy in Chronic Kidney Disease"
M. Kamura, K. Koyama, K. Omachi, R. Fukuda, Y. Kai, MA. Suico, T. Shuto, H. Kai

"A possible application of lncuCyte on the analysis of life span in C.eleganse"
M. Moriuchi, T. Shuto, Y. Nakano, M. A. Suico, H. Kai

"GLP-1 RECEPTOR AGONIST EXTENDIN 4 EXACERBATES MUCUS HYPERSECRETORY PHENOTYPE IN EPITHELIAL NA+ CHANNEL-OVEREXPRESSI NG CELLS AND MICE"
H. Nohara, T. Shuto, S. Kamei, H. Fujikawa, M. A. Suico, R. A. Caldwell, D. C. Gruenert, H. Kai

"The effect of optimized weak current on Alzheimer's Disease pathology"
G. Okita and Hirofumi Kai

"Characterization of the Intracellular Behavior of COL4A5 and Clarification of Molecular Mechanism of Alport Syndrome"
K. Omachi, M. Kamura, K. Teramoto, R. Fukuda, Y. Kai, M. A. Suico, T. Shuto, H. Kai

"INCREASED IL-17C PRODUCTION BY THE TLR3 LIGAND POLY{l :C) IN PRIMARY CYSTIC FIBROSIS AIRWAY EPITHELIAL CELLS"
Y. Tasaki, K. Ueno-Shuto, T. Shuto, S. Kamei, K. Onuki, M. A. Suico, H. Kai

"Low-intensity direct electrical current stress suppresses pro inflammatory cytokines expression via inhibition of multiple signaling pathways"
Y. Tsurekawa, l. Shitanda, S. Matsuyama, K. Mitsutake, R. Fukuda, Y. Kai, M. A. Suico, T. Shuto, H. Kai

"FAM105A modulates the inflammatory response to lipopolysaccharide"
T. Yokota, R. Fukuda, M. A. Suico, T. Shuto, H. Kai

WCP2014 17th World Congress of Basic & Clinical Pharmacology(2014.7.13-18)
The Cape Town International Convention Centre, Cape Town, South Africa

"The endoplasmic reticulum-oriented drug development for familial amyloid polyneuropathy "
K. Chosa, R. Yamakawa, T. Sato, T. Yokoyama, M. Mizuguchi, M. Suico, T. Shuto, H. Kai

2013 ASCB Annual Meeting(2013.12.14-18)
The New Orleans Ernest N. Morial Convention Center, New Orleans, Lousiana,USA

"The endoplasmic reticulum-oriented drug development for familial amyloid polyneuropathy "
K. Chosa, R. Yamakawa, T. Sato, T. Yokoyama, M. Mizuguchi, M. Suico, T. Shuto, H. Kai

"Low-intensity direct electrical current stress suppresses pro-inflammatory cytokines expression via inhibition of multiple signaling pathways"
I. Shitanda, S. Matsuyama, K. Mitsutake, R. Fukuda, Y. Kai, M. Suico, T. Shuto, H. Kai

"The pharmacological evaluation of expectorant in mucous obstructive pulmonary disease mouse model"
Y. Sakaguchi, T. Shuto, S. Kamei, H. Nohara, C. Matsumoto, T. Ono, M. A. Suico, H. Kai

"Enhanced IL-17C production by the TLR3 ligand Poly(I:C) in cystic fibrosis airway epithelial cells"
Y. Tasaki, T. Shuto, K. Ueno-Shuto, K. Onuki, M. Suico, H. Kai

Xth ISTERH 2013 (2013.11.18-22)
Keio Plaza Hotel Tokyo,Tokyo, Japan

"A novel splicing variant of zinc transporter ZIP2 controls mucus hypersecretory phenotype in CF and CF-like airway epithelial cells "
Kamei Shunsuke, Shuto Tsuyoshi, Matsumoto Chizuru, Sakaguchi Yuki, Nohara Hirofumi, Ann Suico M, Kai Hirofumi

IXth International Symposium on Familial Amyloidotic Polyneuropathy (2013.11.10-13)
Auditorio do Centro de Convencoes Antonio Seabra Moggi,Rio de Janeiro, Brazil

" The endoplasmic reticulum-oriented drug development for transthyretin familial amyloid polyneuropathy"
Keisuke Chosa , Ruiko Yamakawa , Takashi Sato , Takeshi Yokoyama , Mineyuki Mizuguchi , Mary Ann Suico ,Tsuyoshi Shuto , Hirofumi Kai

27th Annual North American Cystic Fibrosis Conference (2013.10.17-19)
Salt Lake Convention Center, Salt Lake City, Utah, USA

"Increased IL-17C Production by the TLR3 Ligand Poly (I:C) in Primary Cystic Fibrosis Airway Epithelial Cells"
Shuto Tsuyoshi, Shuto Keiko, Onuki Kouhei, Tasaki Yukihiro, Suico Mary Ann, Kai Hirofumi

"A novel splicing variant of zinc transporter ZIP2 controls mucus hypersecretory phenotype in CF and CF-Like airway epithelial cells "
Kamei Shunsuke, Shuto Tsuyoshi, Ueno-Shuto Keiko, Matsumoto Chizuru, Sakaguchi Yuki, Nohara Hirofumi, Ann Suico M, Caldwell Ray A, Gruenert Dieter C, Kai Hirofumi

Cytokine 2013 (2013.9.29-10.3)
Hyatt Regency San Francisco, San Francisco, Carfornia, USA

"Increased IL-17C Production by the TLR3 Ligand Poly (I:C) in Primary Cystic Fibrosis Airway Epithelial Cells"
Tsuyoshi Shuto, Keiko Ueno-Shuto, Kouhei Onuki, Yukihiro Tasaki, Mary Ann Suico, Hirofumi Kai

"Lipopolysaccharide Decreases SIGIRR/TIR8 Gene Expression by Suppressing Sp1 via TLR4-p38 Mapkinase Pathway in Monocytes and Neutrophils"
Keiko Ueno-Shuto, Tsuyoshi Shuto, Kosuke Kato, Miki Sato, Keizo Sato, Hiromichi Sakai, Tomomi Ono, Mary Ann Suico, Yuji Uchida, Naofumi Tokutomi, Hirofumi Kai

15th International congress of immunology (2013.8.22-27)
Mico Milano Congressi, Milano, ITALY

"Specific pulse-width mild electrical stimulation induces p53 activation via p38 MAPK and ameliorates LPS-induced inflammatory cytokine response"
R. Fukuda, ○K. Omachi, M. A. Suico, K. Koyama, Y. Kai, S. Matsuyama, K. Mitsutake, S. Morino-Koga, T. Shuto, H. Kai

"Crucial role of basal p53 in attenuation of inflammation and fibrosis in hereditary glomerular nephritis, Alport syndrome"
R. Fukuda, K. Koyama, T. Koga, Y. Kai, K. Omachi, K. Motomura, M. A. Suico, T. Shuto, H. Kai

"Mild electrical stimulation with heat shock ameliorates nephritis and proteinuria in mouse model of X-linked alport syndrome "
Y. Kai, T. Koga, R. Fukuda, S. Morino-Koga, M. A. Suico, K. Koyama, T. Sato, T. Shuto, H. Kai

VI International Congress on Stress Proteins in Biology and Medicine (2013.8.18-22)
Edge conference Centre, Sheffield, UK

"Beneficial effects and their molecular mechanisms of specific pulse width mild electrical stress as physical medicine"
H. Kai, T. Kondo, M.A. Suico, T. Shuto, E. Araki

"Specific pulse width mild electrical stress increases stress resistance and suppresses fat accumulation via activation of LKB1-AMPK signaling pathway."
Shingo Matsuyama, Masataka Moriuchi, Mary Ann Suico, Tsuyoshi Shuto and Hirofumi Kai

ASCB 2012 Annual Meeting (2012.12.15-19) San Francisco, CA, USA
"p53 regulates the Ets transcription factor MEF/Elf4 via MDM2."
M. Suico, R. Miyakita, K. Koyama, M. Taura,T. Shuto, H. Kai

Quality Control From Molecules to Organelles(2012.9.19-22)Heidelberg, Germany
"STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein"
Hirofumi Kai, Takashi Sato, Misato Sho, Yasuhiro Sako, Mary-Ann Suico, Tsuyoshi Shuto

ASCB 51st Annual Meeting (2011.12.3-7)Denver, Colorado, USA
"Lucidenic acids-rich extract from antlered from of Ganoderma lucidum enhances TNFα induction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK"
M. Sato, K. Watanabe, T. Shuto, S. Mizunoe, S. Suzuki. M. Ann Suico, T. Ikeda, H. Kai

"Mild electrical stimulation with heat shock ameliorates diabetic nephropathy."
Y. Okamoto, S. Morino-Koga, T. Koga, K. Omachi, M. Suico, T. Shuto, H. Kai,

"Tsukushi differentially modulates TLR2- and TLR4-mediated signaling in murine macrophages "
K. Watanabe, T. Shuto, M. Sato, K. Onuki, M. Suico, K. Ohta, H. Kai

"Protective effects of p53 in a mouse model of progressive hereditary kidney disease Alport syndrome. "
R. Fukuda, K. Koyama, T. Koga, Y. Kai, M. A. Suico, T. Shuto, H. Kai

5th Young Investigators Symposium on Clinical Pharmaceutical Sciences(2011.11.26-27)Nagoya,Japan
"Camostat mesilate improves the mucus hypersecretory and emphysema-like phenotypes in airway-specific -epithelial Na+ channel-transgenic mice"
Tomomi Ono, Tsuyoshi Shuto, Chizuru Matsumoto, Yuki Sakaguchi, Shunsuke Kamei, Mary Ann Suico, Hirofumi Kai

"Mild electrical stimulation suppresses pro-inflammatory cytokines expression via inhibition of multiple signaling pathways "
Ihori Shitanda, Yuishiro Shimauchi, Saori Morino-Koga, Shuichiro Yano, Tomoaki Koga, Shingo Matsuyama, Mary Ann Suico, Tsuyoshi Shuto, Hirofumi Kai

"Evaluation of pulmonary phenotypes in low-mortality airway specific β-epithelial Na+ channel-transgenic mice by DNA microarray and invasive lung function measurement"
Yuki Sakaguchi, Tsuyoshi Shuto, Tomomi Ono, Chizuru Matsumoto, Takuya Sugahara, Shunsuke Kamei, Mary Ann Suico, Hirofumi Kai

The 27th International Kumamoto Medical Bioscience Symposium(2011.11.23)Kumamoto,Japan
【招待講演】
"Intracellular trafficking of amyloidogenic TTR and its therapeutic implications"
Hirofumi Kai

8th International Symposium on Familial Amyloidotic Polyneuropathy (2011.11.20-22)Kumamoto,Japan
"Posttranslational N-glycosylation regulates the quality control of transthyretin in the ER"
Takashi Sato, Yasuhiro Sako, Misato Sho, Mamiko Momohara, Hideki Nishitoh, Koichi Kokame, Masayuki Kaneko, Mary Ann Suico, Tsuyoshi Shuto, Tomoaki Koga, Saori Morino-Koga, Ikuo Wada, Hirofumi Kai

"Endoplasmic reticulum quality control regulates the fate of transthyretin variants in the cell"
Takashi Sato, Seiko Susuki, Mary Ann Suico, Masanori Miyata, Yukio Ando, Mineyuki Mizuguchi, Tsuyoshi Shuto, Hirofumi Kai

"The endoplasmic reticulum-associated degradation of transthyretin variants is negatively regulated by BiP in mammalian cells"
Takashi Sato, Seiko Susuki, Masanori Miyata, Mamiko Momohara, Mary Ann Suico, Tsuyoshi Shuto, Yukio Ando, Hirofumi Kai

"Role of the glutamic acid 54 residue in transthyretin stability and thyroxine binding"
Misato Sho, Masanori Miyata, Takashi Sato, Mineyuki Mizuguchi, Teruya Nakamura, Shinji Ikemizu, Yoshiaki Suwa, Hiroshi Morioka, Yukio Ando, Mary Ann Suico, Tsuyoshi Shuto, Yuriko Yamagata, Hirofumi Kai

"The crystal structure of the green tea polyphenol(-)-epigallocatechin gallate-transthyretin complex reveals a novel binding site distinct from the thyroxine binding site"
Misato Sho, Masanori Miyata, Takashi Sato, Teruya Nakmura, Shinji Ikemizu, Mami Chirifu, Mineyuki Mizuguchi, Yoshiaki Suwa, Hiroshi Morioka, Mary Ann Suico, Tsuyoshi Shuto, Yuriko Yamagata, Hirofumi Kai

25th Annual North American Cystic Fibrosis CONFERENCE(2011.11.3-5)Anaheim,California
"IL-17A primes cystic fibrosis airway epithelial cells to increase IL-8 expression in the presence of bacterial components."
S. Mizunoe ; S. Tuyoshi ; S. Suzuki ; C. Matsumoto ; K. Ueno-Shuto ; M. Suico ; B.J.Scholte ; D.C. Gruenert ; H . Kai

"Evaluation of pulmonary phenotypes in low-mortality airway-specific B-epithelial Na+ channel-transgenic mice by DNA microarray and invasive lung function measurements."
T. Ono ; C . Matsumoto ; Y . Sakaguchi ; T . Shuto ; T . Sugahara ; A . Mizuno ; M . Suico ; H . Kai

"Camostat mesilate improves the mucus hypersecretory and emphysema-like phenotypes in airway-specific B-epithelial Na+ channel-transgenic mice "
C . Matsumoto ; T . Ono ; Y . Sakaguchi ; T . Shuto ; T . Sugahara ; A . Mizuno ; M . Suico . H . Kai

5th International Congress on Stress Response in Biology and Medicine (2011.8.21-25) Quebec,Canada
"HRD1-dependent endoplasmic reticulum-associated degradation pathway is involved in the clearance of transthyretin variant."
Misato Sho, Takashi Sato, Yasuhiro Sako, Mamiko Momohara, Hideki Nishitoh, Masayuki Kaneko, Mary Ann Suico, Tsuyoshi Shuto and Hirofumi Kai

"Mild electrical stimulation suppresses fat accumulation and increases stress resistance via mitochondrial membrane potential-dependent activation of AMPK. "
Shingo Matsuyama , Shuichiro Yano , Saori Morino , Yuichiro Shimauchi, Mary Ann Suico, Tsuyoshi Shuto and Hirofumi Kai

50th ASCB Annual Meeting Program(2010.12.11-15)Philadelphia,USA
"Posttranslational regulation of ATP binding cassette transporter G5 and G8 by HRD1."
S. Suzuki, T. Shuto, T. Sato, T. Takada, M. Kaneko, M. Suico, T. Koga, S. Morino, H. Suzuki, H. Kai

"Mef/Elf4 transactivation by E2F1 is inhibited by p53."
M. Suico, M. Taura, R. Fukuda, T. Koga, T. Shuto, T. Sato, S. Morino, S. Okada, H. Kai

"Posttranslational N-glycosylation is required for the efficient ERAD of Transthyretin variants."
T. Sato, Y. Sako, M. Momohara, M. Sho, H. Nishitoh, M. Kaneko, M. Suico, T. Shuto, I. Wada, H. Kai.

"Endoplasmic reticulum-associated degradation of Transthyretin variant is mediated by HRD1 dependent pathway."
Y. Sako, T. Sat, M. Momohara, M. Sho, H. Nishitoh, M. Kaneko, M. Suico, T. Shuto, H. Kai.

"IL-17A primes Cystic Fibrosis bronchial epithelial cells to increase TLR2/4 responses."
S. Mizunoe, T. Shuto, C. Matsumoto, K. Ueno-Shuto, S. Suzuki, K. Watanabe, M. Suico, T. Koga, T. Sato, D.C. Gruenert, H. Kai.

The 3rd International Symposium on Protein Community(2010.9.13-17)Nara,Japan
"Posttranslational N-glycosylation is required for the efficient ERAD of transthyretin variants."
Takashi Sato, Yasuhiro Sako, Mamiko Momohara, Misato Sho, Hideki Nishitoh, Masayuki Kaneko, Mary Ann Suico, Tsuyoshi Shuto and Hirofumi Kai

2010 Global COE-IMEG Joint Summer Retreat Seminar in Aso(2010.9.9-10)Kumamoto,Japan
"(MEF)/ELF4 transactivation by E2F1 is inhibited by p53."
Mary Ann Suico

"Molecular biological analysis of mucous obstruction in airway-specific --epithelial Na+ channel transgenic mice."
Ai Mizuno

"Assessment of pulmonary mechanics in airway-specific --epithelial Na+ channel
transgenic mice by invasive pulmonary function testing."
Tomomi Ono

"Effect of camostat on the pulmonary phenotype of airway-specific --epithelial Na+
channel transgenic mice."
Chizuru Matsumoto

"Mild electrical stimulation improves fat metabolism in glucose-fed obese C. elegans
model."
Shingo Matsuyama

"Studies on Alport syndrome associated protein-1 in kidney of X-linked Alport syndrome mouse model."
Ryosuke Fukuda

"IL-17A primes Cystic Fibrosis bronchial epithelial cells to increase TLR2/4 responses."
Shota Mizunoe

"Screening of peptides that inhibit the secretion of transthyretin variant."
Misato Sho

"The effect of mild electrical stimulation with heat shock on high glucose-cultured
podocytes and its implication for diabetic nephropathy."
Yuka Okamoto

"Posttranslational regulation of WT and mutant BCRP by Derlin proteins."
Takashi Sugiyama

"Mild electrical stimulation suppresses Th1 cytokines expression via inhibition of nuclear factor BB."
Yuichiro Shimauchi

"Proteomics approach to identify proteins regulating the fate of transthyretin in the cell ."
Mamiko Momohara

"Posttranslational regulation of ATP binding cassette transporter G5 and G8 by HRD1"
Shingo Suzuki

"D18G TTR variant, an originally non-glycosylated protein, is subject to post-translational N-linked glycosylation in the process of endoplasmic reticulum-associated degradation."
Takashi Sato

"Screening of the factors involved in ER-associated degradation of D18G Transthyretin."
Yasuhiro Sako

"The Ganoderma lucidum extracts as a source of novel modulators of p38 and c-Jun
N-terminal kinase."
Kenji Watanabe


第14回国際免疫学会議(ICI)(2010.8.22-27)Kobe,Japan

"IL-17A primes cystic fibrosis bronchial epithelial cells to increase TLR2/4 responses."
S. Miuznoe, S. Tsuyoshi, C. Matsumoto, S. Suzuki, M. Suico,T. Koga, T. Sato, D. C. Gruenert, H. Kai.

"Mild electrical stimulation suppresses pro-inflammatory cytokines expression via inhibition of NF-kB activation"
Y. Shimauchi, S. Morino, S. Yano, M. Suico, T. Shuto, H. Kai.

"Toll-like receptor 3 is up-regulated by p53 and is induced by anti-cancer drugs to potentiate poly I:C-induced tumor cell apoptosis."
M. S. Suico, M. Taura, R. Fukuda, A. Eguma, T. Shuto, T. Koga, T. Sato, H. Kai.

Academia Sinica-Kumamoto University Joint Conference on Organogenesis in Academia Sinica(2010.4.7-10)Taipei,Taiwan
"Bio-electrics: its application in basic and clinical sciences."
Hirofumi Kai

"Increased expression of toll-like receptor-2 (TLR2) during bacterial infection, ER stress-related inflammation, and in cystic fibrosis and its modulation by curcumin."
Tsuyoshi Shuto

The 4th International Congress on Stress Responses in Biology and Medicine
(2009.10.6-9) Sapporo, Japan

"Combination of heat shock and mild electrical stimulation improves insulin resistance and visceral fat accumulation"
S. Morino, S. Yano, T. Matsuno, Y. Shimauchi, S. Matsuyama, T. Kondo, MA. Suico, T. Shuto, E. Araki, H. Kai

"Endoplasmic reticulum stress increases the expression of toll-like
receptor-2 in epithelial cells"
S.Shimasaki, T.Shuto, T.Koga, T.Sato, S.Morino, M.Suico, H.Kai

Cell Stress Society International 2009 (2009.10.6-9) Sapporo, Japan
"The endoplasmic reticulum-associated degradation of transthyretin variants is negatively regulated by BiP."
T. Sato, S. Susuki, M. Miyata, M. Momohara, Y. Sako, M.A. Suico, T. Shuto, H. Kai

"Mild electrical stimulation and heat shock induCombination treatment ces
cell death in hypertrophic adipocytes"
Shingo Matsuyama, Tomoko Matsuda, Saori Morino, Shuichiro Yano,Tatsuya
Kondo,
Mary Ann Suico, Tsuyoshi Shuto, Eiichi Araki, Hirofumi Kai

 

Global COE-IMEG Joint Summer Retreat Seminar
(2009.9.3-4) Kumamoto, Japan

“Mild electrical stimulation with heat shock ameliorates insulin resistance by enhancing insulin signaling”
S. Morino, S. Yano, T. Matsuno, Y. Shimauchi, S. Matsuyama, T. Kondo, MA. Suico, T. Shuto, E. Araki, H. Kai

FASEB SUMMER RESEARCH CONFERENCES, From unfolded proteins in the endoplasmic reticulum to disease (2009.6.7-12) Vermont, USA
"The endoplasmic reticulum-associated degradation of transthyretin variants is negatively regulated by BiP in mammalian cells."
T. Sato, S. Susuki, M. Miyata, M. Momohara, M.A. Suico, T. Shuto, Y. Ando, H. Kai

"The role of Glu54 in transthyretin for protein stability, thyroxine binding and secretion from the cells."
M. Miyata, T. Sato, M. Mizuguchi, T. Nakamura, S. Ikemizu, Y. Nabeshima, S. Susuki, Y. Suwa, H. Morioka, Y. Ando, M.A. Suico, T. Shuto, T. koga, Y. Yamagata, H. Kai

The Kumamoto University Global COE International Joint Symposium on Cell Fate Regulation Research: Molecular Basis and Therapeutic Potentials
(2009.4.9-10) Kumamoto, Japan

“A novel approach for improvement of insulin resistance and visceral fat accumulation”
S. Morino, T. Kondo, K. Sasaki, H. Adachi, MA. Suico, E. Sekimoto, T. Matsuda, T. Shuto, E. Araki, H. Kai

The American Society for Cell Biology 48th Annual Meeting (2008.12.13-7) San Francisco, USA
"p53 Regulates TLR3 Expression and Function in Human Epthelial Cell Lines"
A. Eguma,M. Taura, M. Suico,T. Shuto,T. Koga, K. Komatsu, T.Komune, T, Sato, H. Saya, J. Li, H. Kai

" Curcumin Inhibits Peptidoglycan-Mediated Inflammatory Response in Human Cystic Fibrosis Bronchial Epithelial Cells through Inhibition of TLR2 Gene"
Y. Ohira, T.Shuto,S. Shimasaki,K. Watanabe, M. Suico,H. Kai.


The 22nd Annual North American Cystic Fibrosis Conference(2008.10.23-25) Orland, Florida, USA
"ER RETENTION OF CFTR IS CRUCIAL FOR SP1-DEPENDENT UP-REGULATION OF TLR2 EXPRESSION IN ΔF508-CFTR-EXPRESSING CF BRONCHIAL EPITHELIAL CELLS"
Shimasaki,S.; Shuto,T.; Watanabe,K.; Ohira,Y.; Furuta,T.; Suico,M.S.; Gruenert,D.C.; Kai,H.

"INCREASED SCRATCHING BEHAVIOR AND SUSCEPTIBILITY TO DERMATITIS IN MITE-INEFCTED ΔF508 CFTR MICE"
Mizunoe,S.; Hashimoto,Y.; Shuto,T.; Tomita,A.; Takano,N.; Takeya,M.; Scholte,B.J.; Suico,M.S.; Niibori,A.; Sugahara,T.; Kai,T.


VIIth International Symposium on Familial Amyloid Polyneuropathy and Ist International Workshop on Hereditary Amyloidosis(2008.9.2-5)London,UK
"The endoplasmic reticulm retention and degradation of transthyretin are regulated by the molecular chaperone BiP in mammalian cells"
Seiko Susuki, Takashi Sato, Masanori Miyata, Mary Ann Suico, Tsuyoshi Shuto, Yukio Ando and Hirofumi Kai

"The role of coat protein complex II machinery on the secretion, endoplasmic reticulum retention and endoplasmic reticulum-associated degradation of transthyretin"
Takashi Sato,Seiko Susuki, Masanori Miyata, Mary Ann Suico, Tsuyoshi Shuto, Yukio Ando, Hirofumi Kai

"Glu54 mutations in transthyretin affect thyroxine binding and tetramer stability, resulting in aggressive familial amyloid polyneuropathy"
Masanori Miyata, Takashi Sato,Seiko Susuki, Mineyuki Mizuguchi, Yukio Ando, Mary Ann Suico, Tsuyoshi Shuto, Yuriko Yamagata and Hirofumi Kai

Joint International Symposium on Cell Fate Regulation: Development,
Degeneration and Regeneration in the Central Nervous System (2008.
July 15-17) Rochester, NY, USA

“Intracellular protein traffic in familial amyloidosis polyneuropathy”
Hirofumi Kai

“p53 regulates TLR3 expression in human epithelial cell lines”
Mary Ann Suico

“Genetic and epigenetic regulation of TLR2 during inflammation”
Tsuyoshi Shuto

“NFAT signaling is negatively regulated by CYLD via a deubiquitination-dependent mechanism”
Tomoaki Koga

“Glucocorticoids inhibit Nontypeable Haemophilus influenzae induced MUC5AC mucin expression via MAPK Phosphatase-1-dependent inhibition of p38 MAPK”
Kensei Komatsu


Gordon Research Conferences BIOLOGY OF ACUTE RESRIRATORY INFECTION (2008.3.9-14) Ventura,
California
" Tumor Suppressor Cylindromatosis acts as a negative regulator for nontypeable Haemophilus influenzae-induced Toll-like receptor 7 expression in epithelial cells. "
Tomoaki Koga

" Elucidation of negative regulatory mechanism of Pseudomonas aeruginosa flagellin-induced TLR5 signaling by membrane-tethered mucin,MUCI."
Kosuke Kato

" Muc1 mucin is a negative regulator of Toll like receptor signaling."
Keiko Ueno

The 1st Kumamoto University Global COE International Symposium on Cell Fate Regulation (1. 16, 2008, Kumamoto)

Endoplasmic reticulum quality control regulates the fate of transthyletin variants in the cell.
Sato, K, Seiko Susuki, Mary Ann Suico, Masanori Miyata, Yukio Ando, Mineyuki Mizuguchi, Makoto Takeuchi, Mizuki Dobashi, Tsuyoshi Shuto and Hirofumi Kai

Hsp72 up-regulation improves glucose homeostasis and insulin resistance in type 2 diabetes mouse models.
Morino, S, Tatsuya Kondo, Kazunari Sasaki, Hironori Adachi, Erika Sekimoto, Shuichiro Yano, Tomoko Matsuda, Mary Ann Suico, Tsuyoshi Shuto, Eiichi Araki,  Hirofumi Kai

The role of BiP on secretion and ERAD of transthyretin variants.
Susuki, S, Takashi Sato, Mary Ann Suico, Masanori Miyata, Tsuyoshi Shuto, Hirofumi Kai

IFN-g suppresses Hsp27 expression and enhances cell death induced by hyperthermia.
Oba, M., Yano, S., Shuto T., Suico, MA., Kai, H.

DNA demethylation-dependent enhancement of toll-like receptor-2 gene expression in cystic fibrosis epithelial cells involves SP1-activated transcription.
Shimasaki, S.

Functional analysis of calreticulin on epithelial sodium channel (ENaC) biosynthesis.
Sugahara,T., Ueno, K., Shuto, T., Watanabe, E., Mizunoe, S., Kitamura, K., Maekawa, A., Tomita, K., Suico, M.A., and Kai, H.

Glu54 mutations of transthyretin decrease thyroxine binding and tetramer stability, resulting in aggressive familial amyloid polyneuropathy.
Miyata, M, Takashi Sato, Mizuguchi Mineyuki, Teruya Nakamura, Shinji Ikemizu, Makoto Takeuchi, Seiko Susuki, Yukio Ando, Mary Ann Suico, Tsuyoshi Shuto, Yuriko Yamagata and Hirofumi Kai

Tumor Suppressor CYLD Acts as a Negative Regulator for Bacteria-induced NFAT Signaling.
Koga, T, Jae Hyang Lim, Hirofumi Jono, Un Hwan Ha, Haidong Xu, Hajime Ishinaga, Saori Morino, Chen Yan, Hirofumi Kai, and Jian-Dong Li

The American Society for Cell Biology 47th Annual Meeting (2007.12.01-5)
Washington, DC., USA
“Phosphatidic Acid Metabolism Regulates the Intracellular Trafficking of CFTR.”
S. Mizunoe,Y. Hashimoto,T. Okiyoneda,K. Harada,K. Ueno,T. Sugahara,A. Yamashita,T. Shuto, M. Suico, H. Kai

“The Expression of Myelid-1-like Factor (MEF/Elf4), an ETS Transcription Factor, Is Modulated by p53.”
M. Taura, K. Komatsu, A. Eguma, T. Koga, N. Araki, H. Saya, M. Suico, T. Shuto, H. Kai

“Investigation of the Mechanism of Severe Familial Amyloidotic Polyneurophaty.”
M. Miyata, T. Sato, S. Susuki, T. Nakamura, S Ikemizu, M. A. Suico, T. Shuto, M. Mizuguchi, Y. Ando, Y. Yamagata, H. Kai

“IFN-gamma Enhances the Induction of Cell Death by Heat-shock and Cisplatin through Hsp27 Down-Regulation.”
M. Oba, S. Yano, T. Shuto, M. Suico, H. Kai

Global COE-IMEG Joint Summer Retreat Seminar (2007.9.28-29)
Kumamoto
“ER quality control regulates the fate of transthyletin variants in the cells”
Takashi Sato

“A new therapeutic approach to ameliorate hyperglycemia in mouse models of type 2 diabetes”
Saori Morino

“Functional analysis of calreticulin on epithelial sodium channel (ENaC) biosynthesis”
Takuya Sugahara

“The role of BiP on secrtion and ERAD of transthyretin variant”
Seiko Susuki

“IFN-gamma suppresses Hsp27 expression and enhances cell death induced by hyperthermia”
Mariko Oba

“DNA demethylation-dependent enhancement of toll-like receptor-2 gene expression in cystic fibrosis epithelial cells involves Sp1-activated transcription”
Shogo Shimasaki

“The combinational effect of mild electrical stimulation and heat shock on acute gastric ulcer models”
Tomoko Matsuda

“Phosphatidic acid metabolism regulates the intracellular trafficking and retrotranslocation of CFTR”
Shota Mizunoe

“A new therapeutic approach to ameliorate neurodegenerative diseases”
Erika Sekimoto

“BCRP (Breast Cancer Resistance Protein) is degraded by the Rma1/Ubc6/Derlin1 ubiquitin conjugation machinary. ̄Novel approach for the breast cancer therapy”
Takashi Sugiyama

“The down-regulation mechanism of Hsp27 expression by IFN-gamma”
Syuichiro Yano

“The role of ETS transcription factor MEF that regulates p53 expression and function”
Kensei Komatsu

“Elucidation of the role of degradation-associated molecules in the degradation of ATP-binding cassette family, ABCG5 and ABCG8”
Akiko Niibori

“The mechanism of severe familial amyloid polyneuropathy caused by transthyletin variants at position 54”
Masanori Miyata

“p53 positively regulates the expression and function of Toll-like receptor 3”
Ayaka Eguma

“p53 regulates the expression and function of ETS transcription factor MEF”
Manabu Taura

“Intracellular behavior of Y114C TTR”
Miyuki Kugimiya

“Elucidation of TLR2 regulatory mechanism in Neutrophil-like HL-60 cells differentiated by DMSO”
Yuko Ohira

Cilia,Mucus & Mucociliary Interactions(2007.2.4-9)Ventura, California
" Phosphomiositide 3-Kinase is Activated by MUC1 but notResponsible for MUC1-induced Suppressin of TLR5 Signaling"
Kousuke Kato,Hirofumi Kai, and K.Chul Kim


The American Society for Cell Biology 46th Annual Meeting (2006.12.09-13)
San Diego, California
“Bafilomycin A1-Sensitive Pathway Is Required for the Maturation of Cystic
Fibrosis Transmembrane Conductance Regulator.”
A. Niibori, T. Okiyoneda, K. Harada, T. Kohno, H. Kusuhara, T. Takada, T. Shuto, M. Suico, Y. Sugiyama, H. Kai


Joint Meeting of The Society for Leukocyte Biology and The International Endotoxin and Innate Immunity Society(2006.11.9-11)San Antonio(アメリカ)
“Increased expression of TLR4 during dimethylsulfoxide-induced neutrophilic differentiation of HL-60 cells ”
Tsuyoshi Shuto, Takashi Furuta, Yuko Ohira, Shogo Shimasaki, Dieter C.Gruenert, Judy Cheung, Mary Ann Suico, Hirofumi Kai

“ MUC1 mucin is a negative regulator of TLR signaling”
K.Ueno, T.Koga, D.Golenbock, H.Kai, K.C.Kim


XI International Symposium on Amyloidosis (2006.11.5-9)Wood Hole(アメリカ)
“Inhibition of intracellular tetramerization induces the proteosomal degradation of amyloidogenic transthyretin variants”
Takashi Sato, Seiko Susuki,


The 20th Annual North American Cystic Fibrosis Conference(2006.11.2-5)Denver (アメリカ)
“FUNCTIONAL ANALYSIS OF ER MOLECULAR CHAPERONES ON EPITHELIAL SODIUM CHANNEL(ENaC)BIOSYNTHESIS
Sugahara,T.; Ueno,K.; Kitamura,K.; Maekawa,A.; Shuto,T.; Hashimoto,Y.; Okiyoneda,T.; Harada,K.; Suico,M.; Kai,H.


The 4th Asian Congress of Hyperthermic Oncology (ACHO) & The 23rd Japanese Congress of Hyperthermic Oncology (JCHO)(2006.9.22-23)Nara
“Vitamines K1 and K2 potentiate hyperthermia by down-regulating Hsp72 expression in vitro and in vivo
Mary Ann Suico, Shuji Shimohara, Toru Murakami, Mari Morikawa, Junko Matsuo, Shin-ichi Nagayama,Tsuyoshi Shuto, Tsukasa Okiyoneda, Isao Yamatsu, Toru Mizushima, Tatsuya Shimasaki, Hirofumi Kai

“Hyperthermia suppresses the cytotoxicity of mouse and human NK cells via down regulation of perforin/granzyme B expression”
Toru Murakami,Tomoaki Koga, Hideki Harada, Seow Shi Tea, Seiji Okada, Mary Ann Suico,Tsuyoshi Shuto, Hirofumi Kai

“IFN-γ down-regulates Hsp-27 expression and enhances the induction of cell death by hyperthermia and cisplatin”
Mariko Oba, Tsuyoshi Shuto, Shuichiro Yano, Takashi Furuta, Mary Ann Suico, Hirofumi Kai


20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress (2006.6.18-23) Kyoto
“The activity of the Ets transcription factor Elf4/Myeloid Elf-1-like Factor, is regulated by SUMO and acetylation in epithelial cells”
Mary Ann Suico, Hideaki Nakamura, Zhuo Lu, Hisato Saitoh, Tsukasa Okiyoneda, Tsuyoshi Shuto, Mitsuyoshi Nakao, Hirofumi Kai

“Role of membrane phospholipids in the intracellular trafficking of CFTR”
Yasuaki Hashimoto, Tsukasa Okiyoneda, Kazutsune Harada, Keiko Ueno, Takuya Sugahara, Atsushi Yamashita, Tsuyoshi Shuto, Mary Ann Suico, Hirofumi Kai

“Oxidized LDL increases the expression of resistin in 3T3-L1 adipocytes at the translational level”
Mariko Tokunaga, Akihiko Kuniyasu, Tsuyoshi Shuto,Hirofumi Kai, Hitoshi Nakayama

“Increased expression of TLR2 and TLR4 during dimethylsulfoxide-induced neutrophilic differentiation of HL-60 cells”
Tsuyoshi Shuto, Takashi Furuta, Mary Ann Suico, Tsukasa Okiyoneda, Hirofumi Kai

“IFN-γ down-regulates Hsp-27 expression and potentiates anti-cancer effects of hyperthermia and chemotherapeutics.”
Mariko Oba, Tsuyoshi Shuto, Shuichiro Yano, Takashi Furuta, Mary Ann Suico, Tsukasa Okiyoneda, Hirofumi Kai

“Inhibition of intracellular tetramerization induces proteasomal degradation of myloidogenic transthyretin variants.”
Seiko Susuki, Takashi Sato, Masanori Miyata, Yukio Ando, Tsuyoshi Shuto, Tsukasa Okiyoneda, Mary Ann Suico, Hirofumi Kai


American Diabetes Association 66th Scienific Sessions (2006.6.9-13) WASHINGTON,D.C
"Mild Electrical Stimulation with Hyperthermia Ameliorates Insulin Resistance and Glucose Homeostasis in Mice Models of Type 2 Diabetes"
Saori Morino, Tatsuya Kondo, Kazunari Sasaki, Takeomi Yasuda, Erika Sekimoto, Eiichi Araki, Mary Ann Suico,Tsuyoshi Shuto, Hirofumi Kai


The American Society for Cell Biology 45th Annual Meeting (2005.12.10-14) ワシントンD.C.(アメリカ)
"SUMO Modification and Acetylation Regulate the Activity ond Stability of the ETS Transcription Factor,Meyloid Elf-1 like Factor."
H.Nakamura, M.S.Suico, Z.Lu, H.Saitoh, T.Shuto, M.Naoko, H.Kai

"Segregation of CFTR from Conventional Cargo Proteins in the ER-Golgi Intermediate Compartments."
A.NIibori, T.Okiyoneda, T.Kouno, I.Wada, T.Shuto, M.S.Suico, H.Kai

"Curcumin Increases the CFTR Expression by Down-Regulating Calreticulin,a Negative Regulator of CFTR."
K.Harada, T.Okiyoneda, Y.Hashimoto, K.Ueno, K.Nakamura, K,Yamahira, T.Sugahara, T.Shuto, I.Wada, M.S.Suico, H.Kai

"Calnexine Is Important for Inhibition of the ERAD of Incompletely Folded CFTR but Not for the ER Retention."
T.Okiyoneda, A.NIibori, K.Harada, I.Wada, M.Ikawa, T.Kouno, T.Shuto, M.S.Suico, H.Kai

"Development and Characterization of the Cystic Fibrosis Airway Epithelial Cell Lines Complemented with wild-type and F508del CFTR cDNA."
R.Maurisse, J.W.Cheung, B.Illek, H.Fischer, T Shuto, D.C.Gruenert

" Calnexine and Calreticulin Facilitate the Folding of ABCG5/G8 Sterol Transporter Leading to Increase the Cell Surface Expression."
T.Kouno, T.Okiyoneda, A.NIibori,K.Harada,H.Kusuhara, T.Sugiyama, T.Shuto, M.S.Suico,Y.Sugiyama, H.Kai


The 19th Annual North American Cystic Fibrosis Conference(2005.10.20-23) Baltimore (アメリカ)
"CURCUMIN ACCELERATES THE CFTR TRAFFICKING BY DOWN-REGULATING CALRETICULIN,A NEGATIVE REGULATOR OF CFTR"
Harada, K.; Okioneda, T.;Hashimoto,Y.;Ueno,K.;Nakamura,K.;Yamahira,K.;Sugahara,T.; Shuto, T.;Wada,I.; Suico, M.; Kai, H.

"TOLL-LIKE RESEPTOR-2 IS EPRGENETICALLY UP-REGULATED IN CYSTIC FIBROSIS EPITHELIAL CELLS"
Shuto,T.;Furuta,T.;Xu,H.;Li,J.;Cheung,J.;Gruenert,D.C.;Suico,M.S.;Okiyoneda,T.;Kai,H.


The 6th International Symposium on Familial Amyloidotic Polyneuropathy and Other Transthyretin Related Disorders & The 5th International Workshop on Liver Transplanation in Familial Amyloid Polyneuropathy (2005.8.24-26) La Jolla(アメリカ)
"Secretion pattern of TTR differed with mutation"
T.Sato, S.Susuki, Y.Ando, M.Miyata, F.Mikami, T.Shuto, M.Suico, and H.Kai

"Chromium(III) ion and thyroxine cooprate to stabilize the transthyretin tetramer and suppress amyloid formation"
S.Susuki, T.Sato, Y.Ando, F.Mikami, S.Ikemizu, M.Nakamura, O.Suhr, T.Shuto, M.Suico, and H.Kai

The 8th Conference of the International Endotoxin Society(2004.11.15-18)京都
"TLR4 variant Asp299Gly induces hyporesponsiveness to LPS in human epithelial cells"
Tsuyoshi Shuto,Kana Tokuomi,Kosuke Kato,Takashi Furuta,Suganya Viriyakosol,Tsukasa Okiyoneda,Mary Ann Suico,Hirofumi Kai

"Involvement of lipid rafts in lipopolysaccharide-induced down-regulation of surface TLR4 expression in TLR4/MD-2/CD14-CHO cells"
Kosuke Kato,Tsuyoshi Shuto,YokoMori,Suganya Viriyakosol,Tsukasa Okiyoneda,Hidetoshi Arima,Mary Ann Suico,Hirofumi Kai

The American Society for Cell Biology 44rd Annual Meeting (2004.12.4-8) ワシントンD.C.(アメリカ)
" Regulation of Myeloid Elf-1-like Factor (MEF) by Sp1. "
T. Koga, H. Nakamura, M. Taura, M. S. Suico, T. Shuto, Z. Lu, H. Kai

The Eighteenth Annual North American Cystic Fibrosis Conference (2004.10.14-17) セントルイス(アメリカ)
" Calreticulin Controls The Trafficking of CFTR from Golgi to Cell Surface "
Harada, K.; Okioneda, T.; Shuto, T.; Suico, M.; Kai, H.

The 9th World Congress on Advances in Oncology, and 7th International Symposium on Molecular Medicine(2004.10.14-16)クレタ島(ギリシャ)
" The Function and Regulation of MEF, an ETS Transcription Factor, in Epithelial Cells "
Hirofumi Kai, Mary Ann Suico, Tsuyoshi Shuto

Pharmaceutical Sciences World Congress (PSWC2004) (2004.5.29-6.3) 京都
" Discovery of therapeutics for genetic diseases : FAP & cystic fibtosis "
Hirofumi Kai

" Transcriptional regulation of antimicrobial peptide : human beta-defensin 2 "
Zhuo Lu, Mary Ann Suico, Tsuyoshi Shuto, Hirofumi Kai

" Cooperation between chromium(III) ion and thyroxine to stabilize transthyretin tetramer and suppress amyloid fibril formation "
Takashi Sato, Yukio Ando, Fumi Mikami, Shinji Ikemizu, Seiko Susuki, Akira Imasato, Masaki Nakamura, Makoto Anraku, Tsuyoshi Shuto, Mary Ann Suico, Yuriko Yamagata, Hirofumi Kai

" MEF, an ETS transcription factor, up-regulates Iysozyme transcription in epithelial cells through interaction with PML protein "
Mary Ann Suico, Hiroki Yoshida, Yoshiyuki Seki, Tomoko Uchikawa, Zhuo Lu, Tsuyoshi Shuto, Kazuhito Matsuzaki, Mitsuyoshi Nakao, Hirofumi Kai

" Expression of toll-like receptors in normal and cystic fibrosis epithelial cells "
Tsuyoshi Shuto, Takashi Furuta, Mary Ann Suico, Hirofumi Kai

" Calreticulin may be a negative regulator in trafficking of CFTR "
Kazutune Harada, Tsukasa Okiyoneda, kaori Yamahira, Yasuaki Hashimoto, Keiko Ueno, Tsuyoshi Shuto, Mary Ann Suico, Hirofumi Kai

" Molecular mechanisms for LPS-mediated TLR4 internalization in TLR4/MD-2/CD14-CHO cells"
Tsuyoshi Shuto, Yoko Mori, Kosuke Kato, Takashi Furuta, Suganya Viriyakosol, Hidetoshi Arima, Mary Ann Suico, Hirofumi Kai

" ΔF508 CFTR pool in the ER is increased by calnexin overexpression "
Tsukasa Okiyoneda, Kazutune Harada, Motohiro Takeya, Kaori Yamahira, Ikuo Wada, Tsuyoshi Shuto, Mary Ann Suico, Yasuaki Hashimoto, Hirofumi Kai

" Vitamin K2 inhibits the expression of heat shock proteins in vitro and in vitro "
Shuji Shimohara, Mari Morikawa, Toru Murakami, Junko Matsuo, Tsuyoshi Shuto, Hirofuimi kai

Toll 2004 (2004.5.8-11) タオルミナ(イタリア)
" Lipqpqlysaccharide induces downregulation of surface TLR4 expression in TLR4/MD-2/CD14-CHO cells "
Koske Kato, Tsuyoshi Shuto, Yoko Mori, Sugaya Viriyakosol, Mary Ann Suico and Hirofumi Kai

" Increased expression of TLR2/4 and MD-2 in human Cystic fibrosis epithelial cells "
Tsuyoshi Shuto, Takashi Furuta, Jian-Dong Li, Bob J. Scholte, Mary Ann Suico and Hirofumi Kai

The American Society for Cell Biology 43rd Annual Meeting (2003.12.13-17) サンフランシスコ(アメリカ)
"Synergistic up-regulation of MUC5AC mucin transcription by Nontypeable Haemophilus influenzae and PMA"
H. Jono, J. Li

Seventeenth Annual North American Cystic Fibrosis Conference (2003.10.16-19) アナハイム(アメリカ)
"UP-REGULATION OF TOLL-LIKE RECEPTORS IN HUMAN CYSIC FIBROSIS EPITHELIAL CELLS "
SHUTO, T.; FURUTA, T.; LI, J.; SUICO, M; ARIMA, H.; KAI, H.

41ST ANNUAL MEETING OF IDSA 2003 (2003.10.9-12)サンディエゴ(アメリカ)
"Dysregulated Expression Of Toll-Like Recepors In Human Cystic Fibrosis Epithelial Cells"
Tsuyoshi Shuto, Mary Ann Suico

The Awaji International Forum on Infection and Immunity (2003.8.25-28)
"Dysregulated expression of Toll-like recepors in human cystic fibrosis epithelial cells"
SHUTO TSUYOSHI, Furuta Takashi, Li Jian-dong, Suico Mary Ann, Kai Hirofumi

"Regulation of trafficking of wild type CFTR by calreticulin"
HARADA KAZUTSUNE, Yamahira Kaori, Hashimoto Yasuaki, Shuto Tsuyoshi, Suico Mary ann, Kai Hirofumi

42th American Society for Cell Biology Annual Meeting (2002.12.14-18)サンフランシスコ(アメリカ)
"Up-regulation of toll-like receptors in human Cystic Fibrosis epithelial cells"
T. Shuto, J. Li, H. Arima, H. Kai,

"ETS2 is Involved in Transcriptional Regulation of Granulocyte-Macrophage Colony-Stimulating Factor in Human Non-Small Lung Carcinoma Cell Line, A459"
Z. Lu, T. Shuto, H. Arima, H. Kai

"Contribution of caveolines to H+ -K+ -ATPase recycling process in gastric parietal cells"
H. Arima, Y. mori, T. Shuto, H. Kai, C.T. Okamoto

"Calnexin attenuates the ER-associated degradation of immature CFTR"
T. Okiyoneda, K. Harada, K. Yamahira, I. Wada, T. Shuto, H.Kai

"Glucocorticoids inhibit NTHi-induced mucin MUC5AC transcription via a negative cross-talk with p38 MAPK"
A. Imasato, H. Kai, J. Li,

"Myeloid ELF-1-like Factor Localized in PML Nuclear Bodies Up-regulates Lysozyme Transcription in Epithelial Cells"
H. Yoshida, Y. Seki, M.S. Suico, T. Shuto, K. Matsuzaki, M. Nakao, H. Kai

"Chromium Ion Supperesses TTR Amyloidogenesis"
F. Mikami, Y. Ando, A. Imasato, S. Ikemizu, M. Anraku, T. Tajiri, T. Shuto, H. Arima, H. Kai

Sixteenth Annual North American Cystic Fibrosis Conference (2002.10.3-6) ニューオリンズ(アメリカ)
"A MOST COMMOM MUTANT OF CFTR, △F508 CFTR, ACCUMULATES WITH CALNEXIN IN THE INCLUSION BODY-LIKE STRUCTURES DERIVED FROM THE ER."
Okiyoneda, T.; Harada, K.; Yamahira, K.; Shuto, t.; Kai, H.

The 5th International Symposium on Familial Amyloidotic Polyneuropathy and Other Transthyretin Related Disorders & The 4th International Workshop on Liver Transplanation in Familial Amyloid Polyneuropathy
(2002.9.24-27, Matsumoto, JAPAN)
"Transthyretin Amyloidogenesis Altered by Cr3+ and Al3+ "
Fumi Mikami, Yukio Ando, Akira Imasato, Takahiro Tajiri, Takashi Sato, Tsuyoshi Shuto, Hirofumi Kai

The Awaji International Forum on Infection and Immunity (2002.8.24-27)
"Signal transduction mechanism of nontypeable Haemophilus influenzae-induced Toll-lile receptor 2 up-regulation in human epithelial cells"
T. Shuto, A. Imasato, H. Jono, H. Kai, J. Han, A. Cato, S. Akira, J. Li

2nd Innate Immunity Workshop (2002.5.26-30) ミコノス(ギリシャ)
"Functional dissection of ETS transcription factor MEF and its synergistic upregulation of the lysozyme gene expression with KLF family members, UKLF and LKLF"
M. Suico, T. Koyanagi, S.Ise, Z. Lu, A. Hisatsune, Y. Seki, T. Shuto, Y. Isomiya, T. Miyata, H. Kai

"Calnexin and fユF508 CFTR are colocalized in the inclusion body-like structures in the endoplasmic reticulum"
T. Okiyoneda, K. Harada, K. Yamahora, T. Shuto, H. Kai

"ETS2 is involved in protein kinase C-activated expression of granulocyte-macrophage colony-stimulating factor in human airway epithelial cell line, A159"
Z. Lu, K. A. Kim, M.A. Suico, A. Uto, Y. Seki, T. Shuto, H. Kai

"Glucocorticoids synergistically enhance nonthpe-able haemophilus influenzae-induced Toll-like Receptor 2 expression via a negative cross-talk with p38 MAP kinase"
T. Shuto, A. Imasato, H.jono, A. Sakai, H. Xu, T. Watanabe, D.R. Rixter, H. Kai, A. Andalibi, F. Linthicum, Y. l. Guan, J. Han, A.c. Cato, D.J. Lim, S. Akira and J.d. Li

40th American Society for Cell Biology Annual Meeting (2000.12.9-13)サンフランシスコ(アメリカ)
"Reactive Oxygen Species Mediate the Up-regulation of Mucin MUC5AC Transcription by Nontypeable Haemophilus influenzae"
Haidong XU, Beinan Wang, Tsuyoshi Shuto, Hirofumi Kai, David Lim, Jian-Dong Li

"Activation of NF-kB-dependent Transcriptional activity by Nontypeable Haemophilus influenzae Is Mediated by both NIK-IKK-IKBa-dependent and MKK3/6-p38MAP Kinese-dependent pathways"
Tsuyoshi Shuto, Haidong XU, Beinan Wang, Hirofumi Kai, Jiahuai Ham, David Lim, Jian-Dong LI

"A NOVEL CANDIDATE GENE TO RESCUE MISPROCESSING OF △F508 CFTR PRESENT IN MOST PATIENTS WITH CYSTIC FIBROSIS"
Tsukasa Okiyoneda, Hirofumi Jono, Ikuko Wada, Tsuyoshi Shuto, Kazuhisa Yoshitake, Yukari Shibata, Shin-ichi Nagayama, John R.Riordan, Yoichiro Isohama, Takeshi Miyata, Hirofumi Kai

   

 







































































































 

 


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